Do you suffer from Diabetes or know someone that suffers from this condition? There is a particular form of Diabetes that researchers suggest are rare and genetic.
Treating patients with a rare, genetic form of diabetes with therapies aimed at type 2 diabetes could be harmful, and there needs to be a review of treatment guidelines for such cases.The researchers suggest treating patients with a rare form of diabetes called MODY1 with drugs for type 2 diabetes causes insulin-secreting beta cells (green, with blue nucleus) to become stressed and die. This was the conclusion researchers from Washington University School of Medicine in St. Louis, MO, came to in a study published inThe Journal of Biological Chemistry.
Maturity-onset diabetes of the young (MODY1) is a rare, genetic form of diabetes that is often misdiagnosed as type 2 diabetes because the two forms share similar symptoms. MODY1 accounts for 3-5% of all patients with diabetes. However, the researchers suggest the underlying mechanisms of MODY1 are very different to type 2 diabetes, and treating it with drugs for type 2 diabetes appears to kill insulin-secreting beta cells, causing patients to move onto insulin injections much sooner. Within 10 years of diagnosis, many MODY1 patients find themselves having to inject with insulin as a way to keep their blood sugar under control.
First author Dr. Benjamin D. Moore, formerly of Washington University and now at Massachusetts General Hospital, explains that drugs for type 2 diabetes make insulin-secreting beta cells very active, and adds: “But the MODY1 pathway we’ve uncovered shows that stimulating those cells with those drugs can lead to beta cell death. That means these patients can become dependent on insulin injections much sooner.”